(Jho, Eek-hoon)



Seoul National University (Seoul, Korea) B.S.     1986    ȭа


Michigan State University (E. Lansing)  Ph.D.  1995    а 


SUNY at Stony Brook  1995.11 - 1997.2        Post-doctoral Research Scientist


Columbia University (New York)  1997.3 - 2000.12       Associate Research Scientist


縯б ǰ     2001.1 - 2001.8         Brain Pool


  øб а     2001.9 -           




Lee EJ, Seo E, Kim JW, Nam SA, Lee JY, Jun J, Oh S, Park M, Jho E, Yoo KH, Park JH, Kim YK. (2020) TAZ/Wnt--catenin/c-MYC axis regulates cystogenesis in polycystic kidney disease. Proc Natl Acad Sci U S A. Online ahead of print.

Jeong W, Kim S, Lee U, Zhong ZA, Savitsky M, Kwon H, Kim J, Lee T, Cho JW, Williams BO, Katanaev VL, Jho EH. 2020. LDL receptor-related protein LRP6 senses the level of nutrient and regulates Hippo signaling. EMBO Reports 21(9):e50103

A commentary for this work was presented in News & Views in EMBO reports.

This work has been recommended in Faculty Opinions.

Kim S, Kim H, Tan A, Song Y, Lee H, Ying QL, Jho EH. 2020. The distinct role of Tcfs and Lef1 in the self-renewal or differentiation of mouse embryonic stem cells. Int J Stem Cells. 13(2):192-201.

Kim J, Kwon H, Shin YK, Song G, Lee T, Kim Y, Jeong W, Lee U, Zhang X, Nam G, Jeung HC, Kim W, Jho EH. 2020. MAML1/2 promote YAP/TAZ nuclear localization to enhance tumorigenesis. Proc Natl Acad Sci U S A. 117(24):13529-13540.

Kim E, Kang JG, Kang MJ, Park JH, Kim YJ, Kim Y, Kweon TH, Lee HW, Jho EH, Lee Y, Kim SI, Yi EC, Park HW, Yang WH, Cho JW. 2020. O-GlcNAcylation on LATS2 disrupts the Hippo pathway by inhibiting its activity. Proc Natl Acad Sci U S A. 117(25):1459-14269.


Prasad R and Jho EH. 2019. A Concise Review of Human Brain Methylome During Aging and Neurodegenerative Diseases. BMB Rep. 52(10):577-588.

Kim W, Cho YS, Wang X, Park O, Ma X, Kim H, Gan W, Jho EH, Cha B, Jeung YJ, Zhang L, Gao B, Wei W, Jiang J, Chung KS, Yang Y. 2019. Hippo signaling is intrinsically regulated during cell cycle progression by APC/CCdh1. Proc Natl Acad Sci U S A. 116(19):9423-9432.


Jho EH. 2018. Dual role of YAP: oncoprotein and tumor suppressor. J.Thoracic Dis. 10, S3895-S3898.

Cha B, Geng X, Mahamud MR, Zhang JY, Chen L, Kim W, Jho EH, Kim Y, Choi D, Dixon JB, Chen H, Hong YK, Olson L, Kim TH, Merrill BJ, Davis MJ, Srinivasan RS. 2018. Complementary Wnt Sources Regulate Lymphatic Vascular Development via PROX1-Dependent Wnt/-Catenin Signaling. Cell Rep. 25(3):571-584.

Song Y, Lee S, Kim JR, Jho EH. 2018. Pja2 inhibits Wnt/-catenin signaling by reducing the level of TCF/LEF1. Int J Stem Cells.11(2):242-247.

Chung H, Jung H, Jho EH, Multhaupt HAB, Couchman JR, Oh ES. 2018. Keratinocytes negatively regulate the N-cadherin levels of melanoma cells via contact-mediated calcium regulation. BBRC 503(2):615-620.

Song Y, Lee S, Jho EH. 2018. Enhancement of neuronal differentiation by using small molecules modulating Nodal/Smad, Wnt/-catenin, and FGF signaling. BBRC 503(1):352-358.

Lee H, Lee E, Seo J, Jeong M, Lee S, Kim SY, Jho E, Choi CH, Chung J, Song J. 2018. Ubiquitylation and degradation of Adenomatous Polyposis Coli by MKRN1 enhances Wnt/-catenin Signalling. Oncogene 37(31):4273-4286.

Jho EH. 2018. Hippo signaling: Special issue of BMB Reports in 2018. BMB Rep. 51(3):105.

Kim W, Jho EH. 2018. The history and regulatory mechanism of the Hippo pathway. BMB Rep. 51(3):106-118.

Kim Y, Jho EH. 2018. Regulation of the Hippo Signaling Pathway by Ubiquitin Modification. BMB Rep. 51(3):143-150.

Park J, Jung H, Kim K, Lim KM, Kim JY, Jho EH, Oh ES. 2018. D-tyrosine negatively regulates melanin synthesis by competitively inhibiting tyrosinase activity. Pigment Cell Melanoma Res. 31(3):374-383. 


Moon S, Kim J, Jho E. 2018. In vitro NLK Kinase Assay.  Bio-Protocol 7(21):1-10.

Kang DH, Lee DJ, Lee S, Lee SY, Jun Y, Kim Y, Kim Y, Lee JS, Lee DK, Lee S, Jho EH, Yu DY, Kang SW. 2017. Interaction of Tankyrase and Peroxiredoxin II is Indispensable for the Survival of Colorectal Cancer Cells. Nat Comm. 8(1):40.

Kim Y, Jho EH. 2017. Deubiquitinase YOD1: the potent activator of YAP in hepatomegaly and liver cancer. BMB Reports 50(6):281-282.

Ji L, Bishayee K, Sadra A, Choi S, Choi W, Moon S, Jho EH, Huh SO. 2017. Defective neuronal migration and inhibition of bipolar to multipolar transition of migrating neural cells by Mesoderm-Specific Transcript, Mest, in the developing mouse neocortex. Neuroscience 355:126-140.

Kim Y, Kim W, Song Y, Kim JR, Cho K, Moon H, Ro SW, Seo E, Ryu YM, Myung SJ, Jho EH. 2017. Deubiquitinase YOD1 potentiates YAP/TAZ activities through enhancing ITCH stability. Proc Natl Acad Sci U S A. 114:4691-4696.

Highlighted in Hepatic cell news ? April 21, 2017

Cho S, Cha B, Kwon O, Lim J, Shin D, Han D, Ishitani T, Jho EH, Fornace AJ, Cha H. 2017. Wip1 directly dephosphorylates NLK and increases Wnt activity during germ cell development. BBA-Mol. Basis of Disease 330:157-164.

Jang J, Jung Y, Kim Y, Jho EH, Yoon YS. 2017. LPS-induced inflammatory response is suppressed by Wnt inhibitors, Dickkopf-1 and LGK974, in bronchial epithelial cells . Scientific reports 7:41612. (Co-corresponding author)

Moon S, Kim W, Kim S, Kim Y, Song Y, Bilousov O, Kim J, Lee T, Cha B, Kim M, Kim H, Katanaev VL , Jho EH. 2017. Phosphorylation by NLK inhibits YAP-14-3-3-interactions and induces its nuclear localization. EMBO reports. 18(1):61-71.

A commentary for this work was presented in News & Views in EMBO reports.

F1000Prime Recommendations, In F1000Prime, 20 Feb 2017; F1000Prime.com/727114897

EMBO encounters Issue35, Spring 2017. P.19. Selected as a representative paper among published

Papers in EMBO Reports during the Spring of 2017.

Hong AW, Meng Z, Yuan HX, Plouffe SW, Moon S, Kim W, Jho EH, Guan KL. 2017. Osmotic stress-induced phosphorylation by NLK at Ser128 activates YAP. EMBO reports. 18(1):72-86.

Kim W, Kahn SK, Gvozdenovic-Jeremic J, Kim Y, Dahlman J, Kim H, Park O, Ishitani T, Jho EH, Gao B, Yang Y. 2017. Interacting network of Hippo, Wnt/b-catenin and Notch signaling represses liver tumor formation. J Clin Invest. 127(1):137-152.


Kim S, Jho EH. 2016. Merlin, a regulator of Hippo signaling, regulates Wnt/b-catenin signaling. BMB Rep. 49:357-8.

Cha B, Geng X, Mahmud MR, Fu J, Mukherjee A, Kim Y, Jho EH, Kim TH, Kahn ML, Xia L, Dixon B, Chen H, Srinivasan RS. 2016. Mechanotransduction activates Canonical Wnt/b-catenin signaling to promote lymphatic vascular patterning and the development of lymphatic and lymphovenous valves. Genes & Dev. 30(12):1454-69.

Kim M, Kim S, Lee SH, Kim W, Sohn MJ, Kim HS, Kim J, Jho EH. 2016. Merlin inhibits Wnt/?-catenin signaling by blocking LRP6 phosphorylation. Cell Death and Diff. 23(10):1638-47.


Shin DW, Sohn MJ, Kim HS, Lee DJ, Jeon SR, Hwang YJ, Jho EH. 2015. Clinical analysis of spinal stereotactic radiosurgery in the treatment of neurogenic tumors. J Neurosurg Spine. 23(4):429-37.

Kim H, Kim S, Song Y, Kim W, Ying QL, Jho EH. 2015. Dual Function of Wnt Signaling during Neuronal Differentiation of Mouse Embryonic Stem Cells. Stem Cells Int. 2015:459301.

Cha B, Park Y, Hwang BN, Kim SY, Jho EH. 2015. Protein Arginine Methyltransferase 1 Methylates Smurf2. Mol Cells. 38(8):723-8.


Kim M, Jho EH. 2014. Cross-talk Between Wnt/-catenin and Hippo signaling pathways: a brief review. BMB Rep. 47:40-5.

Cho HG, Lee SG, Kim JE, Yu KS, Lee DY, Park PH, Yoon MH, Jho EH, Kim J, Paik SY. 2014. Molecular epidemiology of norovirus GII.4 variants in children under 5 years with sporadic acute gastroenteritis in South Korea during 2006-2013. J Clin Virol. 61:340-344.

Cho HG, Lee SG, Kim WH, Lee JS, Park PH, Cheon DS, Jheong WH, Jho EH, Lee JB, Paik SY. 2014. Acute gastroenteritis outbreaks associated with ground-waterborne norovirus in South Korea during 2008-2012. Epidemiol Infect. 142(12):2604-9.


Jung H, Kim BG, Han WH, Lee JH, Cho JY, Park WS, Maurice MM, Jan JK, Lee MJ, Finley D and Jho EH.  2013. Deubiquitination of Dishevelled by Usp14 is required for Wnt Signaling. Oncogenesis  2:e64.

Cho HG, Choi JH, Lee HK, Mun SK, Lee JB, Jho EH, Kang C and Lim YH. 2013. Oseltamivir-resistant influenza viruses isolated in South Korea from 2005 to 2010.  Arch Virol. 158(11):2365-70.

Choi EJ, Kim S, Jho EH, Song KJ and Kee SH. 2013. Axin expression enhances herpes simplex virus type 1 replication by inhibiting virus-mediated cell death in L929 cells. J. Gen. Virol. 94(7):1636-46.

Kim W, Kim M, and Jho EH. 2013. Wnt/b-catenin signaling: From plasma membrane to nucleus. Biochemical Journal 450(1):9-21. (Invited review)

Cho HG, Choi JH, Kim WH, Hong HK, Yoon MH, Jho EH, Kang C and  Lim YH. 2013. High prevalence of amantadine-resistant influenza A virus isolated in Gyeonggi Province, South Korea, during 2005-2010. Arch Virol. 158(1):241-5.

Kim W, Kim SY, Kim T, Kim M, Bae DJ, Choi HI, Kim IS and Jho EH. 2013. ADP-ribosylation factor regulates Wnt/b-catenin signaling via control of LRP6 phosphorylation. Oncogene  32(28): 3390-6.


Kim W, Kim H, Katanaev V, Lee S, Ishitani T, Cha B, Han JK and Jho EH. 2012. Dual functions of DP1 promote biphasic Wnt-on and Wnt-off states during anteroposterior neural patterning. EMBO J. 31(16):3384-97.

A commentary for this work was presented in Have you seen? in the EMBO J.

Fagotto F. 2012 Polyvalent DP1 keeps the Wnt pathway neat and tidy. EMBO J. 31(16):3377-9.

    This paper has been used for the advertisement of EMBO J in the EMBO J homepage.

This is a Top ten downloads papers during last two weeks of Aug. 2012.

Cha B and Jho EH.  Protein arginine methyltransferases (PRMT) as therapeutic targets. 2012. Expert Opinion on Therapeutic Targets  16(7):651-64. (Invited review).


Kim SY, Kim S, Yun-Choi HS and Jho EH. 2011. Wnt5a potentiates U46619-induced platelet aggregation via the PI3K/Akt pathway. Mol Cells. 32(4):333-6

Lyu J, Jho EH, Lu, W. 2011. Smek promotes histone deacetylation to suppress transcription of Wnt target gene brachyury in pluripotent embryonic stem cells. Cell Research 21(6):911-21

Jung H, Lee SK and Jho EH. 2011. Mest/Peg1 inhibits Wnt signaling via regulation of LRP6 glycosylation. Biochemical Journal 436(2):263-9

Kim SY, Kim S, Kim JM, Jho EH, Park S, Oh D and Yun-Choi HS. 2011. PKC inhibitors RO 31-8220 and Gø 6983 enhance epinephrine-induced platelet aggregation in catecholamine hypo-responsive platelets by enhancing Akt phosphorylation. BMB Report 44(2):140-5

Cha B, Kim W, Kim YK, Hwang BN, Park SY, Yoon JW, Park WS, Cho JW, Bedford MT and Jho EH. 2011. Methylation by protein arginine methyltransferase1 increases stability of Axin, a negative regulator of Wnt signaling. Oncogene 30(20):2379-89

Kim H, Won S, Hwang DY, Lee JS, Kim M, Kim R, Kim W, Cha B, Kim T, Kim D, Costantini F, Jho EH. 2011. Down-regulation of Wnt/b-catenin signaling causes degeneration of hippocampal neurons in vivo. Neuro. Aging. 32(12):2316.e1-2316.e15


Kim SW, Jho EH. 2010. The protein stability of Axin, a negative regulator of Wnt signaling, is regulated by Smad Ubiquitination Regulatory Factor 2 (Smurf2). J. Biol. Chem. 285(47):36420-6

Kim M, Kim H, Jho EH. 2010. Identification of ptpro as a novel target gene of Wnt signaling and its potential role as a receptor for Wnt. FEBS Letters 584(18):3923-28


Jung H, Kim H, Lee SK, Kim R, Kopachik W, Han JK, Jho EH. 2009. Negative feedback regulation of Wnt signaling by Gbg-mediated reduction of Dishevelled. Exp. Mol. Med. 41(10):695-706.

Kim JA, Kang YJ, Park G, Kim M, Park YO, Kim H, Leem SH, Chu IS, Lee JS, Jho EH, Oh IH. 2009. Identification of a Stroma-Mediated Wnt/-catenin Signal Promoting Self-renewal of Hematopoietic Stem Cells in Stem Cell Niche. Stem Cells. 27(6):1318-29.

Kim H, Cheong SM, Ryu J, Jung HJ, Jho EH and Han JK. 2009. Xenopus Wntless and the Retromer complex cooperate to regulate XWnt4 secretion. Mol Cell Biol. 29(8):2118-28.

Kim SM, Choi E, Song, K, Kim S, Seo E, Jho EH, Kee SH. 2009. Axin localizes to mitotic spindles and centrosomes in mitotic cells. Exp Cell Res. 315(6):943-54.

Seo E, Kim S, Jho EH. 2009. Induction of cancer cell-specific death via MMP2 promoter-dependent expression of Bax. BMB reports. 42(4):217-22.

Seo E, Kim H, Kim R, Yun S, Kim M, Han JK, Costantini F, Jho EH. 2009. Multiple isoforms of beta-TrCP display differential activities in the regulation of Wnt signaling. Cell Signal. 21:43-51.


Ahn SM, Byun K, Kim D, Lee K, Yoo JS, Kim SU, Jho EH, Simpson RJ, Lee B. 2008. Olig2-induced neural stem cell differentiation involves downregulation of Wnt signaling and induction of Dickkopf-1 expression. PLoS ONE. 3(12):e3917.


Yun S, Rim Y, Jho EH. 2007. Induced expression of the transcription of tropomodulin 1 by Wnt5a and characterization of the tropomodulin 1 promoter. Biochem Biophys Res Commun. 363:727-32

Seo E, Jho EH. 2007. Axin-independent phosphorylation of APC controls b-catenin signaling via cytoplasmic retention of b-catenin. Biochem Biophys Res Commun. 357:81-6.

Jeon S, Yoon J, Park Y, Jeong W, Kim S, Jho EH, Surh Y, Choi K. 2007. Axin inhibits extracellular signal-regulated kinase pathway by Ras degradation via b-catenin. J. Biol. Chem. 282:14482-92

Lim Y, Park H, Jeon J, Han, I, Kim J, Jho EH, Oh ES. 2007. Focal adhesion kinase is negatively regulated by phosphorylation at tyrosine 407. J. Biol. Chem. 282(14):10398-404.

Im JM, Kim HJ, Kim SW, Jho EH  2007. Wnt/b -catenin signaling regulates expression of PRDC, an antagonist of the BMP-4 signaling pathway. Biochem Biophys Res Commun. 354:296-301.


Shakya R, Jho EH, Kotka P, Wu Z, Kholodilov N, Burke R, D'Agati V, Costantini F. 2005. The role of GDNF in patterning the excretory system. Dev Biol. 283:70-84.

Kim SM, Kim R, Ryu JH, Jho EH, Song KJ, Jang SI, Kee SH.  2005. Multinuclear giant cell formation is enhanced by down-regulation of Wnt signaling in gastric cancer cell line, AGS. Exp Cell Res. 308:18-28.


Choi JK, Park SY, Costantini F, Jho EH*, Joo CK*. 2004. APC is down-regulated by the ubiquitin-proteasome pathway in a process facilitated by Axin. J. Biol. Chem. 279:49188-98. (* Co-corresponding authors)

Shin SY, Kim CG, Jho EH, Rho MS, Kim YS, Kim YH, Lee YH. 2004.  Hydrogen peroxide negatively modulates Wnt signaling through down regulation of beta-catenin.  Cancer Lett. 212:225-31.

Hwang SG, Ryu JH, Kim IC, Jho EH, Jung HC, Kim K, Kim SJ, Chun JS. 2004.  Wnt-7a causes loss of differentiated phenotype and inhibits apoptosis of articular chondrocytes via different mechanisms.  J. Biol .Chem. 279 :26597-604.

Park CS, Kim SI, Lee MS, Youn CY, Kim DJ, Jho EH, Song WK, 2004. Modulation of beta -catenin phosphorylation/degradation by cyclin-dependent kinase 2.  J. Biol. Chem. 279 :19592-9.

SI Kim, CS Park ,MS Lee, MS Kwon, EH Jho, WK Song, 2004. Cyclin-dependent kinase 2 regulates the interaction of Axin with b-catenin. Biochem Biophys Res Commun. 317:478-483.

Hwang KH, Lee EH, Jho EH, Kim JH, Lee do H, Chung SK, Kim EK, Joo CK. 2004.  Accumulation and aberrant modifications of alpha-crystallins in anterior polar cataracts.  Yonsei Med J. 45:73-80.


Lyu J, Costantini F, Jho EH*, Joo CK*, 2003. Ectopic expression of Axin blocks neuronal differentiation of embryonic carcinoma P19 cells. J. Biol. Chem. 278:13487-95. (* Co-corresponding authors)

[Before 2002]

Jho, E., Zhang, T., Domon, C., Joo, C.-k., Freund, N. and Costantini, F., 2002 Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway. Mol Cell Biol. 22, 1172-83.

Julius, M., Schelbert, B., Hsu, W., fitzpatrick, E., Jho, E., Fagotto, F., Costantini, F. and Kitajewski, J.  2000. Domains of Axin and Disheveled required for interaction and functions in Wnt signaling. Biochem Biophys Res Commun. 276,1162-9.

Primot A, Baratte B, Gompel M, Borgne A, Liabeuf S, Romette JL, Jho E, Costantini F, Meijer L. 2000. Purification of GSK-3 by Affinity Chromatography on Immobilized Axin. Protein Expr Purif. 20, 394-404.

Jho, E., Lomvardas, S. and Costantini, F. 1999. A GSK3b phosphorylation site in Axin modulates interaction with b-catenin and Tcf-mediated gene expression. Biochem Biophys Res Commun.   266, 28-35.

Fagotto F*, Jho E*, Zeng L, Kurth T, Joos T, Kaufmann C and Costantini F. 1999. Domains of Axin Involved in Protein-Protein Interactions, Wnt Pathway Inhibition, and Intracellular Localization. J. Cell Biol. 145,741-756.  (* Co-first authors)

Jho, E. and Malbon, C. 1997. Ga12 and Ga13 mediate differentiation of P19 mouse embryonal carcinoma cells in response to retinoic acid.  J. Biol. Chem. 272, 24461-67.

Jho, E., Davis, R. J. and Malbon, C. 1997.  C-jun amino-terminal kinase is regulated by Ga12/Ga13 and obligate for differentiation of P19 embryonal carcinoma cells by the retinoic acid. J. Biol. Chem. 272, 24468-74.