(Jho, Eek-hoon)


Seoul National University (Seoul, Korea) B.S.   1986    ȭа


Michigan State University (E. Lansing)  Ph.D.   1995    а 


SUNY at Stony Brook  1995.11 - 1997.2                    Post-doctoral Research Scientist


Columbia University (New York)  1997.3 - 2000.12       Associate Research Scientist


縯б ǰ     2001.1 - 2001.8              Brain Pool


  øб а     2001.9 - 2005.9              


  øб а     2005.9 - 2010.10            α


  øб а     2010.10 -                   


73. Jho EH. 2018. Dual role of YAP: oncoprotein and tumor suppressor. J.Thoracic Dis. 10, S3895-S3898.

72. Cha B, Geng X, Mahamud MR, Zhang JY, Chen L, Kim W, Jho EH, Kim Y, Choi D, Dixon JB, Chen H, Hong YK, Olson L, Kim TH, Merrill BJ, Davis MJ, Srinivasan RS. 2018. Complementary Wnt Sources Regulate Lymphatic Vascular Development via PROX1-Dependent Wnt/-Catenin Signaling. Cell Rep. 25(3):571-584.

71. Song Y, Lee S, Kim JR, Jho EH. 2018. Pja2 inhibits Wnt/-catenin signaling by reducing the level of TCF/LEF1. Int J Stem Cells.11(2):242-247.

70. Chung H, Jung H, Jho EH, Multhaupt HAB, Couchman JR, Oh ES. 2018. Keratinocytes negatively regulate the N-cadherin levels of melanoma cells via contact-mediated calcium regulation. BBRC 503(2):615-620.

69. Song Y, Lee S, Jho EH. 2018. Enhancement of neuronal differentiation by using small molecules modulating Nodal/Smad, Wnt/-catenin, and FGF signaling. BBRC 503(1):352-358.

68. Lee H, Lee E, Seo J, Jeong M, Lee S, Kim SY, Jho E, Choi CH, Chung J, Song J. 2018. Ubiquitylation and degradation of Adenomatous Polyposis Coli by MKRN1 enhances Wnt/-catenin Signalling. Oncogene 37(31):4273-4286.

67. Jho EH. 2018. Hippo signaling: Special issue of BMB Reports in 2018. BMB Rep. 51(3):105.

66. Kim W, Jho EH. 2018. The history and regulatory mechanism of the Hippo pathway. BMB Rep. 51(3):106-118.

65. Kim Y, Jho EH. 2018. Regulation of the Hippo Signaling Pathway by Ubiquitin Modification. BMB Rep. 51(3):143-150.

64. Park J, Jung H, Kim K, Lim KM, Kim JY, Jho EH, Oh ES. 2018. D-tyrosine negatively regulates melanin synthesis by competitively inhibiting tyrosinase activity. Pigment Cell Melanoma Res. 31(3):374-383. 

63. Moon S, Kim J, Jho E. 2018. In vitro NLK Kinase Assay.  Bio-Protocol 7(21):1-10.

62. Kang DH, Lee DJ, Lee S, Lee SY, Jun Y, Kim Y, Kim Y, Lee JS, Lee DK, Lee S, Jho EH, Yu DY, Kang SW. 2017. Interaction of Tankyrase and Peroxiredoxin II is Indispensable for the Survival of Colorectal Cancer Cells. Nat Comm. 8(1):40.

61. Kim Y, Jho EH. 2017. Deubiquitinase YOD1: the potent activator of YAP in hepatomegaly and liver cancer. BMB Reports 50(6):281-282.

60. Ji L, Bishayee K, Sadra A, Choi S, Choi W, Moon S, Jho EH, Huh SO. 2017. Defective neuronal migration and inhibition of bipolar to multipolar transition of migrating neural cells by Mesoderm-Specific Transcript, Mest, in the developing mouse neocortex. Neuroscience 355:126-140.

59. Kim Y, Kim W, Song Y, Kim JR, Cho K, Moon H, Ro SW, Seo E, Ryu YM, Myung SJ, Jho EH. 2017. Deubiquitinase YOD1 potentiates YAP/TAZ activities through enhancing ITCH stability. Proc Natl Acad Sci U S A. 114:4691-4696.

Highlighted in Hepatic cell news – April 21, 2017

58. Cho S*, Cha B*, Kwon O, Lim J, Shin D, Han D, Ishitani T, Jho EH, Fornace AJ, Cha H. 2017. Wip1 directly dephosphorylates NLK and increases Wnt activity during germ cell development. BBA-Mol. Basis of Disease 330:157-164. (*: co-first authors.)

57. Jang J, Jung Y, Kim Y, Jho EH*, Yoon YS*. 2017. LPS-induced inflammatory response is suppressed by Wnt inhibitors, Dickkopf-1 and LGK974, in bronchial epithelial cells . Scientific reports 7:41612. (*: co-corresponding authors)

56. Moon S, Kim W, Kim S, Kim Y, Song Y, Bilousov O, Kim J, Lee T, Cha B, Kim M, Kim H, Katanaev VL, Jho EH. 2017. Phosphorylation by NLK inhibits YAP-14-3-3-interactions and induces its nuclear localization. EMBO reports. 18(1):61-71.

A commentary for this work was presented in News & Views in EMBO reports.

F1000Prime Recommendations, In F1000Prime, 20 Feb 2017; F1000Prime.com/727114897

EMBO encounters Issue35, Spring 2017. P.19. Selected as a representative paper among published

Papers in EMBO Reports during the Spring of 2017.

55. Hong AW, Meng Z, Yuan HX, Plouffe SW, Moon S, Kim W, Jho EH, Guan KL. 2017. Osmotic stress-induced phosphorylation by NLK at Ser128 activates YAP. EMBO reports. 18(1):72-86.

54. Kim W, Kahn SK, Gvozdenovic-Jeremic J, Kim Y, Dahlman J, Kim H, Park O, Ishitani T, Jho EH, Gao B, Yang Y. 2017. Interacting network of Hippo, Wnt/b-catenin and Notch signaling represses liver tumor formation. J Clin Invest. 127(1):137-152.

53. Kim M, Kim S, Lee SH, Kim W, Sohn MJ, Kim HS, Kim J, Jho EH. Merlin inhibits Wnt/-catenin signaling by blocking LRP6 phosphorylation. Cell Death Differ. 2016 Oct;23(10):1638-47.

52. Kim S, Jho EH. Merlin, a regulator of Hippo signaling, regulates Wnt/-catenin signaling. BMB Rep. 2016 Jul;49(7):357-8.

51. Cha B, Geng X, Mahamud MR, Fu J, Mukherjee A, Kim Y, Jho EH, Kim TH, Kahn ML, Xia L, Dixon JB, Chen H, Srinivasan RS. Mechanotransduction activates canonical Wnt/-catenin signaling to promote lymphatic vascular patterning and the development of lymphatic and lymphovenous valves. Genes Dev. 2016 Jun 15;30(12):1454-69.

50. Shin DW, Sohn MJ, Kim HS, Lee DJ, Jeon SR, Hwang YJ, Jho EH. Clinical analysis of spinal stereotactic radiosurgery in the treatment of neurogenic tumors. J Neurosurg Spine. 2015 Oct;23 (4):429-37.

49. Cha B, Park Y, Hwang BN, Kim SY, Jho EH. Protein Arginine Methyltransferase 1 Methylates Smurf2. Mol Cells. 2015 Aug;38(8):723-8.

48. Kim H, Kim S, Song Y, Kim W, Ying QL, Jho EH. Dual Function of Wnt Signaling during Neuronal Differentiation of Mouse Embryonic Stem Cells. Stem Cells Int. 2015;2015:459301

47. Cho HG, Lee SG, Kim WH, Lee JS, Park PH, Cheon DS, Jheong WH, Jho EH, Lee JB, Paik SY. Acute gastroenteritis outbreaks associated with ground-waterborne norovirus in South Korea during 2008-2012. Epidemiol Infect. 2014 Dec;142(12):2604-9.

46. Cho HG, Lee SG, Kim JE, Yu KS, Lee DY, Park PH, Yoon MH, Jho EH, Kim J, Paik SY. Molecular epidemiology of norovirus GII.4 variants in children under 5 years with sporadic acute gastroenteritis in South Korea during 2006-2013. J Clin Virol. 2014 Nov;61(3):340-4.

45. Kim M, Jho EH. Cross-talk between Wnt/-catenin and Hippo signaling pathways: a brief review. BMB Rep. 2014 Oct;47(10):540-5. Review.

44.H Jung, B-G Kim, WH Han, JH Lee, J-Y Cho, WS Park, MM Maurice, J-K Han, MJ Lee, D Finley and E-h JhoDeubiquitination of Dishevelled by Usp14 is required for Wnt signaling. Oncogenesis. 2013 Aug 19;2:e64.

43. Choi EJ, Kim S, Jho EH, Song KJ and Kee SH. 2013. Axin expression enhances herpes simplex virus type 1 replication by inhibiting virus-mediated cell death in L929 cells. J. Gen. Virol. 2013 Jul;94(Pt 7):1636-46.

42. Cho HG, Choi JH, Lee HK, Mun SK, Lee JB, Jho EH, Kang C and Lim YH. Oseltamivir-resistant influenza viruses isolated in South Korea from 2005 to 2010.  Arch Virol. 2013 May 21. [Epub ahead of print]

41. Kim W, Kim M, Jho EH. Wnt/-catenin signalling: from plasma membrane to nucleus. Biochem J. 2013 Feb 15;450(1):9-21. (Invited review)

40. Cho HG, Choi JH, Kim WH, Hong HK, Yoon MH, Jho EH, Kang C and  Lim YH. 2013. High prevalence of amantadine-resistant influenza A virus isolated in Gyeonggi Province, South Korea, during 2005-2010. Arch Virol. 2013 Jan;158(1):241-5.

39. Wantae Kim, Sang-Yeob Kim, Taeyoon Kim, Minhye Kim, Dong-Jun Bae, Hye-In Choi, In-San Kim, and Eek-hoon Jho. ADP-ribosylation factors 1 and 6 (Arf1/6) regulate Wnt/-catenin signalingvia control of LRP6 phosphorylation. Oncogene. 2013 Jul 11;32(28):3390-6.

38. Kim W, Kim H, Katanaev V, Lee S, Ishitani T, Cha B, Han JK and Jho EH. Dual functions of DP1 promote biphasic Wnt-on and Wnt-off states during anteroposterior neural patterning. EMBO J. 2012 Jul 6;31(16):3384-97.

37. Cha B and Jho EH.  Protein arginine methyltransferases (PRMT) as therapeutic targets. Expert Opinion on Therapeutic Targets  2012 Jul;16(7):651-64. (Invited review)

36. Kim SY, Kim S, Yun-Choi HS, Jho EH. Wnt5a potentiates U46619-induced platelet aggregation via the PI3K/Akt pathway. Mol Cells. 32(4):333-6]

35. Lyu J, Jho EH, Lu W. Smek promotes histone deacetylation to suppress transcription of Wnt target gene brachyury in pluripotent embryonic stem cells. Cell Res. 2011 Jun;21(6):911-21.

34. Jung H, Lee SK, Jho EH. Mest/Peg1 inhibits Wnt signaling via regulation of LRP6 glycosylation. Biochem J. 22011 Jun 1;436(2):263-9.

33. B Cha, W Kim, YK Kim, BN Hwang, SY Park, JW Yoon, WS Park, JW Cho, MT Bedford and E-h Jho. Methylation by protein arginine methyltransferase 1 increases stability of Axin, a negative regulator of Wnt signaling. Oncogene. 2011 May 19;30(20):2379-89.

32. Kim SW, Jho EH. The protein stability of Axin, a negative regulator of Wnt signaling, is regulated by Smad Ubiquitination Regulatory Factor 2. J. Biol. Chem. 2010 Nov 19;285(47):36420-6.

31. Kim M, Kim H, Jho EHIdentification of ptpro as a novel target gene of Wnt signaling and its potential role as a receptor for Wnt. FEBS Letters. 2010 Sep 24;584(18):3923-8.

30. Kim H, Won S, Hwang DY, Lee JS, Kim M, Kim R, Kim W, Cha B, Kim T, Kim D, Costantini F, Jho EH. Downregulation of Wnt/beta-catenin signaling causes degeneration of hippocampal neurons in vivo. Neurobiol Aging. 32(12):2316.e1-2316.e15

29. Jung H, Kim HJ, Lee SK, Kim R, Kopachik W, Han JK, Jho EHNegative feedback regulation of Wnt signaling by Gbetagamma-mediated reduction of Dishevelled. Exp Mol Med. 2009 Oct 31;41(10):695-706.

28. Kim JA, Kang YJ, Park G, Kim M, Park YO, Kim H, Leem SH, Chu IS, Lee JS, Jho EH, Oh IH. Identification of a stroma-mediated Wnt/beta-catenin signal promoting self-renewal of hematopoietic stem cells in the stem cell niche. Stem Cells. 2009 Jun;27(6):1318-29.

27. Seo E, Kim S, Jho EH. Induction of cancer cell-specific death via MMP2 promoterdependent Bax expression. BMB Rep. 2009 Apr 30;42(4):217-22.

26. Kim SM, Choi EJ, Song KJ, Kim S, Seo E, Jho EH, Kee SH. Axin localizes to mitotic spindles and centrosomes in mitotic cells. Exp Cell Res. 2009 Apr 1;315(6):943-54.

25. Kim H, Cheong SM, Ryu J, Jung HJ, Jho EH, Han JK. Xenopus Wntless and the retromer complex cooperate to regulate XWnt4 secretion. Mol Cell Biol. 2009 Apr;29(8):2118-28.

24. Ahn SM, Byun K, Kim D, Lee K, Yoo JS, Kim SU, Jho EH, Simpson RJ, Lee B. Olig2-induced neural stem cell differentiation involves downregulation of Wnt signaling and induction of Dickkopf-1 expression. PLoS One. 2008;3(12):e3917

23. Seo E, Kim H, Kim R, Yun S, Kim M, Han JK, Costantini F, Jho EHMultiple isoforms of beta-TrCP display differential activities in the regulation of Wnt signaling. Cell Signal. 2009 Jan;21(1):43-51.

22. . . . Wnt ȣ ֽ . ߻ . 2007; 11, 141-153.

21. Yun S, Rim Y, Jho EHInduced expression of the transcription of tropomodulin 1 by Wnt5a and characterization of the tropomodulin 1 promoter. Biochem Biophys Res Commun. 2007 Nov 23;363(3):727-32.

20. Seo E, Jho EHAxin-independent phosphorylation of APC controls beta-catenin signaling via cytoplasmic retention of beta-catenin. Biochem Biophys Res Commun. 2007 May 25;357(1):81-6.

19. Jeon SH, Yoon JY, Park YN, Jeong WJ, Kim S, Jho EH, Surh YJ, Choi KY. Axin inhibits extracellular signal-regulated kinase pathway by Ras degradation via beta-catenin. J Biol Chem. 2007 May 11;282(19):14482-92.

18. Lim Y, Park H, Jeon J, Han I, Kim J, Jho EH, Oh ES. Focal adhesion kinase is negatively regulated by phosphorylation at tyrosine 407. J Biol Chem. 2007 Apr 6;282(14):10398-404.

17. Im J, Kim H, Kim S, Jho EHWnt/beta-catenin signaling regulates expression of PRDC, an antagonist of the BMP-4 signaling pathway. Biochem Biophys Res Commun. 2007 Mar 2;354(1):296-301.

16. Shakya R, Jho EH, Kotka P, Wu Z, Kholodilov N, Burke R, D'Agati V, Costantini F. The role of GDNF in patterning the excretory system. Dev Biol. 2005 Jul 1;283(1):70-84.

15. Kim SM, Kim R, Ryu JH, Jho EH, Song KJ, Jang SI, Kee SH. Multinuclear giant cell formation is enhanced by down-regulation of Wnt signaling in gastric cancer cell line, AGS. Exp Cell Res. 2005 Aug 1;308(1):18-28.

14. Choi J, Park SY, Costantini F, Jho EH*, Joo CK*. Adenomatous polyposis coli is down-regulated by the ubiquitin-proteasome pathway in a process facilitated by Axin. J Biol Chem. 2004 Nov 19;279(47):49188-98. (* Co-corresponding authors).

13. Shin SY, Kim CG, Jho EH, Rho MS, Kim YS, Kim YH, Lee YH. Hydrogen peroxide negatively modulates Wnt signaling through downregulation of beta-catenin.  Cancer Lett. 2004 Aug 30;212(2):225-31.

12. Hwang SG, Ryu JH, Kim IC, Jho EH, Jung HC, Kim K, Kim SJ, Chun JS. Wnt-7a causes loss of differentiated phenotype and inhibits apoptosis of articular chondrocytes via different mechanisms.  J Biol Chem. 2004 Jun 18;279(25):26597-604.

11. Hwang KH, Lee EH, Jho EH, Kim JH, Lee DH, Chung SK, Kim EK, Joo CK. Accumulation and aberrant modifications of alpha-crystallins in anterior polar cataracts. Yonsei Med J. 2004 Feb 29;45(1):73-80.

10. Park CS, Kim SI, Lee MS, Youn CY, Kim DJ, Jho EH, Song WK. Modulation of beta-catenin phosphorylation/degradation by cyclin-dependent kinase 2. J Biol Chem. 2004 May 7;279(19):19592-9.

11. SI Kim, CS Park ,MS Lee, MS Kwon, EH Jho, WK Song. Cyclin-dependent kinase 2 regulates the interaction of Axin with b-catenin. Biochem Biophys Res Commun. 2004 317:478-483.

10. Cho H and Jho EH. Development of inducible siRNA expression system.  Life Science & Technology 2004 31, 26-31.

9. Lyu J, Costantini F, Jho EH*, Joo CK*. Ectopic expression of Axin blocks neuronal differentiation of embryonic carcinoma P19 cells. J Biol Chem. 2003 Apr 11;278(15):13487-95. (* Co-corresponding authors).

8. Jho EH, Zhang T, Domon C, Joo CK, Freund JN, Costantini F. Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway. Mol Cell Biol. 2002 Feb;22(4):1172-83.

7. Primot A, Baratte B, Gompel M, Borgne A, Liabeuf S, Romette JL, Jho EH, Costantini F, Meijer L. Purification of GSK-3 by affinity chromatography on immobilized axin. Protein Expr Purif. 2000 Dec;20(3):394-404.

6. Julius, M., Schelbert, B., Hsu, W., fitzpatrick, E., Jho, E., Fagotto, F., Costantini, F. and Kitajewski, J. Domains of Axin and Disheveled required for interaction and functions in Wnt signaling. Biochem Biophys Res Commun. 2000 276,1162-9.

5. Jho, E., Lomvardas, S. and Costantini, F. A GSK3beta phosphorylation site in Axin modulates interaction with b-catenin and Tcf-mediated gene expression. Biochem Biophys Res Commun. 1999 266, 28-35.

4. Fagotto F*, Jho E*, Zeng L, Kurth T, Joos T, Kaufmann C and Costantini F. Domains of Axin Involved in Protein-Protein Interactions, Wnt Pathway Inhibition, and Intracellular Localization. J. Cell Biol. 1999 145,741-756  (* Co-first authors).

3. Jho EH, Davis RJ, Malbon CC. c-Jun amino-terminal kinase is regulated by Galpha12/Galpha13 and obligate for differentiation of P19 embryonal carcinoma cells by retinoic acid. Jho EH, Davis RJ, Malbon CC. J Biol Chem. 1997 Sep 26;272(39):24468-74.

2. Jho EH, Malbon CC. Galpha12 and Galpha13 mediate differentiation of P19 mouse embryonal carcinoma cells in response to retinoic acid. J Biol Chem. 1997 Sep 26;272(39):24461-7.

1. .  Ű ߻ ȭ Wnt ȣ . ѱ ڼд 2002; 14, 30-34.