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Wnt pathway in Drosophila and Vertebrate

drosophila.jpgvertebrate.jpg

                                                                                 Seto, E.S. and Bellen, H.J., TRENDS in cell biology, 2004

 

 

 

 

Wnt genes in various organisms

wntvariation.jpg

                                                                                   Cadigan, K.M, and Nusse, R., GENES & DEVELOPMENT, 1997

 

 

 

 

Canonical/ Noncanonical Pathway

 

 

 

 

Role of Domains in Dishevelled

                                               Habas, R. et al., GENES & DEVELOPMENT, 2003

 

 

 

 

Relation with LRP5/6 and Antagonists

                                                                                                                                Kawano, Y. and Kypta, R.,  JCS,  2003

 

 

 

 

The effect of Wnt in Transcriptional activity

 

 

 

 

Competition of Transcriptional Activators and Repressors

 

 

 

 

Interactions between proteins in Wnt signaling and the approximate sites of binding.

     http://www.stanford.edu/~rnusse/pathways/binding.html